CONCLUSIONS
Treatment for hypogonadal men who desire fertility
preservation continues to be a challenge for physi-
cians. Low dose HCG appears to protect and support
continued spermatogenesis when given in conjunc-
tion with injectable or topical TRT.
REFERENCES
1. Mulligan T, Frickl MF, Zuraw QC et al: Prevalence
of hypogonadism in males aged at least 45 years:
the HIM study. Int J Clin Practice 2006;
60:
762.
2. Corona G, Rastrelli G, Monami M et al: Hypogo-
nadism as a risk factor for cardiovascular mor-
tality in men: a meta-analytic study. Eur J Endo-
crinol 2011;
165:
687.
3. Corona G, Monami M, Rastrelli G et al: Testos-
terone and metabolic syndrome: a meta-analysis
study. J Sex Med 2011;
8:
272.
4. Zarrouf FA, Artz S, Griffith J et al: Testosterone
and depression: systematic review and meta-
analysis. J Psychiatr Pract 2009;
15:
289.
5. de Souza GL and J. Hallak: Anabolic steroids and
male infertility: a comprehensive review. BJU Int
2011;
108:
1860.
6. Coviello AD, Matsumoto AM, Bremner WJ et al:
Low-dose human chorionic gonadotropin maintains
intratesticular testosterone in normal men with
testosterone-induced gonadotropin suppression.
J Clin Endocrinol Metab 2005;
90:
2595.
7. Araujo AB, O’Donnell AB, Brambilia DJ et al:
Prevalence and incidence of androgen deficiency
in middle-aged and older men: estimates from
the Massachusetts Male Aging Study. J Clin
Endocrinol Metab 2004;
89:
5920.
8. Lethbridge-Çejku M, Schiller JS and Bernadel L:
Summary Health Statistics for U.S. Adults: Na-
tional Health Interview Survey, 2002. Vital and
Health Statistics. Series 10, No. 222. Data from
the National Health Survey. Hyattsville: Depart-
ment of Health and Human Services, Centers for
Disease Control and Prevention, National Center
for Health Statistics 2004.
9. Moskovic DJ, Katz DJ, Akhavan A et al: Clomi-
phene citrate is safe and effective for long-term
management of hypogonadism. BJU Int 2012;
110:
1524.
10. Burnett-Bowie SA, Roupenian KC, Dere ME et al:
Effects of aromatase inhibition in hypogonadal
older men: a randomized, double-blind, placebo-
controlled trial. Clin Endocrinol, Epub ahead of
print June 25, 2008.
11. Anderson RA and Wu FC: Comparison between
testosterone enanthate-induced azoospermia and
oligozoospermia in a male contraceptive study. II.
Pharmacokinetics and pharmacodynamics of once
weekly administration of testosterone enanthate.
J Clin Endocrinol Metab 1996;
81:
896.
12. Dohle GR, Smit M and Weber RF: Androgens and
male fertility. World J Urol 2003;
21:
341.
13. Turek PJ, Williams RH, Gilbaugh JH 3rd et al: The
reversibility of anabolic steroid-induced azoosper-
mia. J Urol 1995;
153:
1628.
14. Cooper TG, Noonan E, von Eckardstein S et al:
World Health Organization reference values for
human semen characteristics. Human Reprod Up-
date 2010;
16:
231.
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