Institutes of Health K12 Scholar supported by a Male Repro-
ductive Health Research Career Development Physician-
Scientist Award (HD073917-01) from the Eunice Kennedy
Shriver National Institute of Child Health and Human Devel-
opment Program. The authors have no other relevant affilia-
tions or financial involvement with any organization or entity
with a financial interest in or financial conflict with the sub-
ject matter or materials discussed in the manuscript apart
from those disclosed.
References
[1] Centers for Disease Control and Prevention. Current cigarette
smoking among adults
United States, 2011. MMWR Morb
Mortal Wkly Rep 2012;61:889
94.
[2] The health consequences of smoking: a report of the surgeon
general. Atlanta, GA: Office of the Surgeon General; 2004.
[3] Practice Committee of American Society for Reproductive Medi-
cine. Definitions of infertility and recurrent pregnancy loss:
a committee opinion. Fertil Steril 2013;99:63.
[4] Thoma ME, McLain AC, Louis JF, Trumble AU, Sundaram R,
Buck Louis GM. Prevalence of infertility in the United States as
estimated by the current duration approach and a traditional con-
structed approach. Fertil Steril 2013;99:1324
31; e1321.
[5] Kovac JR, Pastuszak AW, Lamb DJ. The use of genomics, proteo-
mics, and metabolomics in identifying biomarkers of male infertil-
ity. Fertil Steril 2013;99:998
1007.
[6] Ramlau-Hansen CH, Thulstrup AM, Aggerholm AS, Jensen MS,
Toft G, Bonde JP. Is smoking a risk factor for decreased semen
quality? A cross-sectional analysis. Hum Reprod 2007;22:188
96.
[7] Ku
nzle R, Mueller MD, Hänggi W, Birkhäuser MH, Drescher H,
Bersinger NA. Semen quality of male smokers and nonsmokers in
infertile couples. Fertil Steril 2003;79:287
91.
[8] Saaranen M, Suonio S, Kauhanen O, Saarikoski S. Cigarette
smoking and semen quality in men of reproductive age. Andrologia
1987;19:670
6.
[9] Zhang JP, Meng QY, Wang Q, Zhang LJ, Mao YL, Sun ZX. Effect
of smoking on semen quality of infertile men in Shandong, China.
Asian J Androl 2000;2:143
6.
[10] Murawski M, Saczko J, Marcinkowska A, Chwi
l
kowska A,
Marcinkowska A, Grybos
´M
,B
a
n
a
s
´ T. Evaluation of superoxide
dismutase activity and its impact on semen quality parameters of
infertile men. Folia Histochem Cytobiol 2007;45:S123
6.
[11] Sanocka D, Miesel R, Jedrzejczak P, Kurpisz MK. Oxidative stress
and male infertility. J Androl 1996;17:449
54.
[12] Gaur DS, Talekar M, Pathak VP. Effect of cigarette smoking on
semen quality of infertile men. Singapore Med J 2007;48:119
23.
[13] Chia SE, Ong CN, Tsakok FM. Effects of cigarette smoking on
human semen quality. Arch Androl 1994;33:163
8.
[14] Merino G, Lira SC, Martinez-Chequer JC. Effects of cigarette
smoking on semen characteristics of a population in Mexico. Arch
Androl 1998;41:11
15.
[15] Povey AC, Clyma JA, McNamee R, Moore HD, Baillie H,
Pacey AA, Cherry NM. Modifiable and non-modifiable risk factors
for poor semen quality: a case-referent study. Hum Reprod
2012;27:2799
806.
[16] Dikshit RK, Buch JG, Mansuri SM. Effect of tobacco consumption
on semen quality of a population of hypofertile males. Fertil Steril
1987;48:334
6.
[17] Hassa H, Yildirim A, Can C, Turgut M, Tanir HM, Senses T,
Can C, et al. Effect of smoking on semen parameters of men
attending
an
infertility
clinic.
Clin
Exp
Obstet
Gynecol
2006;33:19
22.
[18] Pasqualotto FF, Sobreiro BP, Hallak J, Pasqualotto EB, Lucon AM.
Cigarette smoking is related to a decrease in semen volume in a
population of fertile men. BJU Int 2006;97:324
6.
[19] Vine MF, Margolin BH, Morrison HI, Hulka BS. Cigarette
smoking and sperm density: a meta-analysis. Fertil Steril 1994;61:
35
43.
[20] Li Y, Lin H, Li Y, Cao J. Association between socio-psycho-beha-
vioral factors and male semen quality: systematic review and
meta-analyses. Fertil Steril 2011;95:116
23.
[21] Liu RZ, Gao JC, Zhang HG, Wang RX, Zhang ZH, Liu XY. Semi-
nal plasma zinc level may be associated with the effect of cigarette
smoking on sperm parameters. J Int Med Res 2010;38:923
8.
[22] Oyeyipo IP, Raji Y, Emikpe BO, Bolarinwa AF. Effects of nicotine
on sperm characteristics and fertility profile in adult male rats:
a possible role of cessation. J Reprod Infertil 2011;12:201
7.
[23] Wong WY, Thomas CM, Merkus HM, Zielhuis GA, Doesburg WH,
Steegers-Theunissen RP. Cigarette smoking and the risk of male fac-
tor subfertility: minor association between cotinine in seminal plasma
and semen morphology. Fertil Steril 2000;74:930
5.
[24] Fuentes A, Muñoz A, Barnhart K, Argu
ello B, Díaz A, Pommer R.
Recent cigarette smoking and assisted reproductive technologies
outcome. Fertil Steril 2010;93:89
95.
[25] Klonoff-Cohen H, Natarajan L, Marrs R, Yee B. Effects of female
and male smoking on success rates of IVF and gamete intra-
fallopian transfer. Hum Reprod 2001;16:1382
90.
[26] Joesbury KA, Edirisinghe WR, Phillips MR, Yovich JL. Evidence
that male smoking affects the likelihood of a pregnancy following
IVF treatment: application of the modified cumulative embryo
score. Hum Reprod 1998;13:1506
13.
[27] Zitzmann M, Rolf C, Nordhoff V, Schräder G, Rickert-Fo
hring M,
Gassner P, Behre HM, Greb RR, Kiesel L, Nieschlag E. Male
smokers have a decreased success rate for in vitro fertilization and
intracytoplasmic sperm injection. Fertil Steril 2003;79:1550
4.
[28] Jensen TK, Jorgensen N, Punab M, et al. Association of in utero
exposure to maternal smoking with reduced semen quality and
testis size in adulthood: a cross-sectional study of 1,770 young
men from the general population in five European countries. Am J
Epidemiol 2004;159:49
58.
[29] Jensen MS, Mabeck LM, Toft G, Thulstrup AM, Bonde JP. Lower
sperm counts following prenatal tobacco exposure. Hum Reprod
2005;20:2559
66.
[30] Storgaard L, Bonde JP, Ernst E, Spanô M, Andersen CY,
Frydenberg M, Olsen J. Does smoking during pregnancy affect
sons
sperm counts? Epidemiology 2003;14:278
86.
[31] Neal MS, Hughes EG, Holloway AC, Foster WG. Sidestream
smoking is equally as damaging as mainstream smoking on IVF
outcomes. Hum Reprod 2005;20:2531
5.
DOI: 10.1080/00325481.2015.1015928
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