Men traditionally have been viewed as being immune
to the ravages of time; however, we are slowly moving
towards an era in which a man’s reproductive age is
considered as important as the woman’s. It is tempting to
speculate that the identification of increased mortality in
the children of men with APA is a harbinger of future
findings that may set guidelines defining the age at which
older men should cautiously proceed with pregnancy.
Conﬂicts of interest:
L.I. Lipshultz has served as a clinical trials
participant, consultant, and speaker for both Auxilium and Endo. J.R.
Kovac, R. Ramasamy, and J. Dupree have nothing to disclose.
Zhu JL, Vestergaard M, Madsen KM, Olsen J. Paternal age and
mortality in children. Eur J Epidemiol 2008;23:443–7.
Kovac JR, Addai J, Smith RP, Coward RM, Lamb DJ, Lipshultz LI. The
effects of advanced paternal age on fertility. Asian J Androl 2013;
Hultman CM, Sandin S, Levine SZ, Lichtenstein P, Reichenberg A.
Advancing paternal age and risk of autism: new evidence from a
population-based study and a meta-analysis of epidemiological
studies. Mol Psychiatry 2011;16:1203–12.
Kong A, Frigge ML, Masson G, et al. Rate of de novo mutations and the
importance of father’s age to disease risk. Nature 2012;488:471–5.
Zollner U, Dietl J. Perinatal risks after IVF and ICSI. J Perinat Med
Jason R. Kovac, Ranjith Ramasamy, James M. Dupree,
Larry I. Lipshultz
Department of Urology, Baylor College of Medicine, Houston,
*Corresponding author. 6624 Fannin Street, #1700, Houston,
TX 77030, USA.
EUROPEAN UROLOGY 65 (2014) 1218–1223