Men traditionally have been viewed as being immune
to the ravages of time; however, we are slowly moving
towards an era in which a man’s reproductive age is
considered as important as the woman’s. It is tempting to
speculate that the identification of increased mortality in
the children of men with APA is a harbinger of future
findings that may set guidelines defining the age at which
older men should cautiously proceed with pregnancy.
Conflicts of interest:
L.I. Lipshultz has served as a clinical trials
participant, consultant, and speaker for both Auxilium and Endo. J.R.
Kovac, R. Ramasamy, and J. Dupree have nothing to disclose.
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mortality in children. Eur J Epidemiol 2008;23:443–7.
Kovac JR, Addai J, Smith RP, Coward RM, Lamb DJ, Lipshultz LI. The
effects of advanced paternal age on fertility. Asian J Androl 2013;
Hultman CM, Sandin S, Levine SZ, Lichtenstein P, Reichenberg A.
Advancing paternal age and risk of autism: new evidence from a
population-based study and a meta-analysis of epidemiological
studies. Mol Psychiatry 2011;16:1203–12.
Kong A, Frigge ML, Masson G, et al. Rate of de novo mutations and the
importance of father’s age to disease risk. Nature 2012;488:471–5.
Zollner U, Dietl J. Perinatal risks after IVF and ICSI. J Perinat Med
Jason R. Kovac, Ranjith Ramasamy, James M. Dupree,
Larry I. Lipshultz
Department of Urology, Baylor College of Medicine, Houston,
*Corresponding author. 6624 Fannin Street, #1700, Houston,
TX 77030, USA.
E-mail address:
(L.I. Lipshultz).
EUROPEAN UROLOGY 65 (2014) 1218–1223